Article
Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Sept 2006
Wang T-N, Chu Y-T, Chen W-Y, Feng W-W, Shih N-H, Hsiang C-H, Ko Y-C
Abstract excerpt
BACKGROUND: Asthma is a multi-factorial disorder caused by complex interactions between genetic and environmental factors. IFN-gamma and IFN regulatory factor 1 (IRF-1) affect Th1/Th2 cytokine balance, and influence the differentiation of Th2 cells, which influence the development of asthma. OBJECTIVE: This study investigated CA repeats polymorphism of the IFN-gamma gene and GT repeats polymorphism of the IRF-1...
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