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Article

Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxin-shock.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2000

Kildsgaard J, Hollmann T J, Matthews K W, Bian K, Murad F, Wetsel R A

Abstract excerpt

The complement anaphylatoxin C3a, on binding the C3aR, mediates numerous proinflammatory activities. In addition, recent in vitro studies with C3a have implicated C3aR as a possible anti-inflammatory receptor. Because of its possible dual role in modulating the inflammatory response, it is uncertain whether C3aR contributes to the pathogenesis of endotoxin shock. Here, the targeted-disruption of the C3aR in mice...

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Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Dose-Response Relationship, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Injections, Intravenous

Share to Interleukin-1

Share to Lipopolysaccharides

Share to Receptors, Complement

Share to Shock, Septic

Source

Identifiers

PMID: 11067891
DOI: 10.4049/jimmunol.165.10.5406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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