Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Vitro Nephrotoxicity Studies of Established and Experimental Platinum-Based Compounds

18 Aug 2021

Abstract excerpt

Cisplatin is one of the most commonly used drugs for the treatment of various solid cancers. However, its efficacy is restricted by severe side effects, especially dose-limiting nephrotoxicity. New platinum-based compounds are designed to overcome this limitation. Previous investigations showed that the platinum(IV)-nitroxyl complex PN149 is highly cytotoxic in various tumor cell lines. In the present study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy-induced organ toxicity mitigation
Share to Chronic Myeloid Leukemia Treatments
Share to Metal complexes synthesis and properties

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34440237
DOI: 10.3390/biomedicines9081033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Vitro Nephrotoxicity Studies of Established and Experimental Platinum-Based CompoundsPMID 34440237Read ↗

Can Cisplatin Therapy Be Improved? Pathways That Can Be TargetedSemantic proximity Read ↗

Epigenetic Mechanisms Involved in Cisplatin-Induced Nephrotoxicity: An UpdateSemantic proximity Read ↗

Plant‐Derived Agents for Counteracting Cisplatin‐Induced NephrotoxicitySemantic proximity Read ↗

Protective Effect of Natural Antioxidants on Reducing Cisplatin-Induced NephrotoxicitySemantic proximity Read ↗

A Comprehensive Review on the Genetic Regulation of Cisplatin-induced NephrotoxicitySemantic proximity Read ↗

Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapySemantic proximity Read ↗

Biomolecular Targets for Platinum Antitumor DrugsSemantic proximity Read ↗

Novel Approaches Towards Development of Non-Classical Platinum-Based Antineoplastic Agents: Design of Platinum Complexes Characterized by an Alternative DNA-Binding Pattern and/or Tumor-Targeted CytotoxicitySemantic proximity Read ↗

Cisplatin and platinum drugs at the molecular level. (Review).Semantic proximity Read ↗

Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic StrategiesSemantic proximity Read ↗

Fresh Platinum Complexes with Promising Antitumor ActivitySemantic proximity Read ↗

Cisplatin and platinum analoguesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.