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Article

Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4.

Biochemical pharmacology - 15 Aug 2014

Tsai Cheng-Yu, Larson Christopher A, Safaei Roohangiz, Howell Stephen B

Abstract excerpt

The copper influx transporter CTR1 is also a major influx transporter for cisplatin (cDDP) in tumor cells. It influences the cytotoxicity of cDDP both in vivo and in vitro. Whereas Cu triggers internalization of CTR1 from the plasma membrane, cDDP does not. To investigate the mechanisms of these effects, myc-tagged forms of wild type hCTR1 and variants in which Y103 was converted to alanine, C189 was converted to...

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Identifiers

PMID: 24967972
DOI: 10.1016/j.bcp.2014.06.019
PMCID: PMC4343213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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