Article
The fading guardian: clinical relevance of TP53 null mutation in high-grade serous ovarian cancers.
Frontiers in immunology - 1 Jan 2023
Biatta Chiara M, Paudice Michele, Greppi Marco, Parrella Veronica, Parodi Alessia, De Luca Giuseppa, Cerruti Gianna Maria, Mammoliti Serafina, Caroti Cinzia, Menichini Paola, Fronza Gilberto, Pesce Silvia, Marcenaro Emanuela, Vellone Valerio G
Abstract excerpt
Background: we evaluated the concordance between immunohistochemical p53 staining and TP53 mutations in a series of HGSOC. Moreover, we searched for prognostic differences between p53 overexpression and null expression groups. Methods: patients affected by HGSOC were included. For each case p53 immunohistochemical staining and molecular assay (Sanger sequencing) were performed. Kaplan-Meier survival analyses were...
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