Article
Mannose-binding lectin polymorphisms in patients with hepatitis C virus infection.
Scandinavian journal of gastroenterology - 1 Sept 2000
Sasaki K, Tsutsumi A, Wakamiya N, Ohtani K, Suzuki Y, Watanabe Y, Nakayama N, Koike T
Abstract excerpt
BACKGROUND: Persistent infection with hepatitis C virus (HCV) leads to liver cirrhosis (LC) and often to liver cancer. Little is known about host factors that determine the variable natural history. Mannose-binding lectin (MBL) is an important constituent of the innate immune system. In white patients there is an association between codon 52 mutation of the MBL gene and persistent hepatitis B virus (HBV)...
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