Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL.

doi:10.1007/s007050050320

Back to search

Article

Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL.

Archives of virology - 1 Jan 1998

Matsushita M, Hijikata M, Ohta Y, Iwata K, Matsumoto M, Nakao K, Kanai K, Yoshida N, Baba K, Mishiro S

Abstract excerpt

We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly-->Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W...

Topics

Adult
Alleles
Carrier Proteins
Case-Control Studies
Collectins
Gene Frequency
Genetic Predisposition to Disease
Genotype
Hepatitis C, Chronic
Humans
Interferons
Japan
Mutation
Point Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.