Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.

The Journal of cell biology - 30 Oct 2000

Pazour G J, Dickert B L, Vucica Y, Seeley E S, Rosenbaum J L, Witman G B, Cole D G

Abstract excerpt

Intraflagellar transport (IFT) is a rapid movement of multi-subunit protein particles along flagellar microtubules and is required for assembly and maintenance of eukaryotic flagella. We cloned and sequenced a Chlamydomonas cDNA encoding the IFT88 subunit of the IFT particle and identified a Chlamydomonas insertional mutant that is missing this gene. The phenotype of this mutant is normal except for the complete...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlamydomonas
Share to Cilia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flagella

Share to Meiosis

Share to Microscopy, Electron, Scanning

Share to Molecular Motor Proteins

Share to Polycystic Kidney, Autosomal Recessive

Share to Repetitive Sequences, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11062270
DOI: 10.1083/jcb.151.3.709
PMCID: PMC2185580

Genes

IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella.PMID 11062270Read ↗

Intraflagellar transport: from molecular characterisation to mechanismSemantic proximity Read ↗

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.Semantic proximity Read ↗

Primary cilia and signaling pathways in mammalian development, health and disease.Semantic proximity Read ↗

Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development.Semantic proximity Read ↗

Combined NGS approaches identify mutations in the intraflagellar transport gene IFT140 in skeletal ciliopathies with early progressive kidney Disease.Semantic proximity Read ↗

TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.Semantic proximity Read ↗

IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.Semantic proximity Read ↗

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motorsSemantic proximity Read ↗

Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella.Semantic proximity Read ↗

Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.Semantic proximity Read ↗

A healthy understanding of intraflagellar transport.Semantic proximity Read ↗

A unified taxonomy for ciliary dyneins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.