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Article

Expression of soluble, recombinant alphavbeta3 integrin fragments in Escherichia coli.

Microbiological research - 1 Sept 2000

Schroeckh V, Hortschansky P, Fricke S, Luckenbach G A, Riesenberg D

Abstract excerpt

No prokaryotic expression of integrin alphavbeta3 has been reported so far. We report here the expression of C-terminally truncated alphavbeta3 receptors in E. coli considering the known features required for dimerization and ligand binding. The expressed protein was insoluble despite of the addition of 'solubilizers' to the culture medium. Osmotic stress conditions combined with added exogenous solutes resulted...

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Identifiers

PMID: 11061185
DOI: 10.1016/s0944-5013(00)80030-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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