Article
A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.
Cancer research - 15 Oct 2000
Winsey S L, Haldar N A, Marsh H P, Bunce M, Marshall S E, Harris A L, Wojnarowska F, Welsh K I
Abstract excerpt
Exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis induction. Multiprotein pathways involved in repairing UV-DNA damage are the base excision, the nucleotide excision, and the homologous double-stranded DNA repair pathways. This study used a sequence-specific primer PCR (PCR-SSP) genotyping...
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