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Article

Polymorphisms in DNA double-strand break repair genes and skin cancer risk.

Cancer research - 1 May 2004

Han Jiali, Colditz Graham A, Samson Leona D, Hunter David J

Abstract excerpt

UV can cause a wide range of DNA lesions. UVA-induced oxidative DNA damage and blocked DNA replication by UVB-induced photoproducts can lead to double-strand breaks (DSBs). We selected 11 haplotype-tagging single nucleotide polymorphisms in three DSB repair genes XRCC2, XRCC3, and LigaseIV and evaluated their associations with skin cancer risk in a nested case-control study within the Nurses' Health Study [219...

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Source

Identifiers

PMID: 15126335
DOI: 10.1158/0008-5472.can-04-0246

Genes

XRCC3
XRCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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