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Article

Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma.

International journal of cancer - 1 Nov 2007

O'Sullivan Gerald C, Tangney Mark, Casey Garret, Ambrose Monica, Houston Aileen, Barry Orla P

Abstract excerpt

The p21-activated kinase 1 (Pak1) is a serine/threonine kinase whose activity is regulated by both Rho GTPases and AGC kinase family members. It plays a role in cytoskeletal remodeling and cell motility as well as cell proliferation, angiogenesis, tumorigenesis and metastasis. An involvement of Pak1 in renal cell carcinoma (RCC), which remains highly refractory to chemotherapy and radiotherapy, remains to be...

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Identifiers

PMID: 17621631
DOI: 10.1002/ijc.22893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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