Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia.

Abstract excerpt

A natural AQP0 mutation, CatTohm, resulted in smaller eyes, and lenses with bilateral dominant cataracts in mice. Our objective was to characterize this mutation and explore the possible reasons for CatTohm causing dominant cataracts. We studied lens morphology, transparency, functional alterations and cytotoxicity. Lens morphology and nuclear fiber cell organization were severely affected. Water permeability...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aquaporins
• Share to Cataract