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Article

Mutations in the founder of the MIP gene family underlie cataract development in the mouse.

Nature genetics - 1 Feb 1996

Shiels A, Bassnett S

Abstract excerpt

The major intrinsic protein (MIP) of the vertebrate eye lens is the first identified member of a sequence-related family of cell-membrane proteins that appears to have evolved by gene duplication. Several members of the MIP family transport water (aquaporins), glycerol and other small molecules i...

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Source

Identifiers

PMID: 8563764
DOI: 10.1038/ng0296-212

Genes

MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8563764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Mutations in the founder of the MIP gene family underlie cataract development in the mouse.PMID 8563764Read ↗

A Novel Missense Mutation in the Gene Encoding Major Intrinsic Protein (MIP) in a Giant Panda with Unilateral Cataract FormationSemantic proximity Read ↗

A novel missense mutation in the gene encoding major intrinsic protein (MIP) in a Giant panda with unilateral cataract formationSemantic proximity Read ↗

Lens transcriptome profile during cataract development in Mip-null mice.Semantic proximity Read ↗

A novel single-base deletional mutation of MIP impairs protein distribution and cell-to-cell adhesion in autosomal dominant cataracts in a Chinese family.Semantic proximity Read ↗

Lens ER-stress response during cataract development in Mip-mutant mice.Semantic proximity Read ↗

Structural function of MIP/aquaporin 0 in the eye lens; genetic defects lead to congenital inherited cataracts.Semantic proximity Read ↗

Congenital hereditary cataracts.Semantic proximity Read ↗

A 5-bp insertion in Mip causes recessive congenital cataract in KFRS4/Kyo rats.Semantic proximity Read ↗

A 16.7 kb deletion in Sipa1l3 is associated with juvenile cataract in mice.Semantic proximity Read ↗

Whole-exome sequencing prioritizes candidate genes for hereditary cataract in the Emory mouse mutant.Semantic proximity Read ↗

Identification of a novel MIP frameshift mutation associated with congenital cataract in a Chinese family by whole-exome sequencing and functional analysis.Semantic proximity Read ↗

A novel mutation in MIP associated with congenital nuclear cataract in a Chinese family.Semantic proximity Read ↗

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