Article
WT1 splicing alterations in Wilms' tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2000
Baudry D, Hamelin M, Cabanis M O, Fournet J C, Tournade M F, Sarnacki S, Junien C, Jeanpierre C
Abstract excerpt
Hereditary and sporadic forms of tumors are generally related to germ-line and somatic mutations of the same tumor suppressor gene. Unexpectedly, in Wilms' tumor, somatic mutations of the WT1 gene were found only occasionally in sporadic cases, although constitutional mutations of this gene are clearly associated with predisposition. It has been suggested that abnormal splicing may be another mode of somatic WT1...
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