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Article

Reduction of axonal caliber does not alleviate motor neuron disease caused by mutant superoxide dismutase 1.

Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2000

Nguyen M D, Larivière R C, Julien J P

Abstract excerpt

It is well established that motor neurons with large axon caliber are selectively affected in amyotrophic lateral sclerosis (ALS). To investigate whether high neurofilament (NF) content and large axonal caliber are factors that predispose motor neurons to selective degeneration in ALS, we generated mice expressing a mutant form of superoxide dismutase 1 (SOD1(G37R)) linked to familial ALS in a context of one...

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Identifiers

PMID: 11050249
DOI: 10.1073/pnas.97.22.12306
PMCID: PMC17337

Genes

SOD1

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