Article
Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998
Couillard-Després S, Zhu Q, Wong P C, Price D L, Cleveland D W, Julien J P
Abstract excerpt
To investigate the role of neurofilaments in motor neuron disease caused by superoxide dismutase (SOD1) mutations, transgenic mice expressing a amyotrophic lateral sclerosis-linked SOD1 mutant (SOD1(G37R)) were mated with transgenic mice expressing human neurofilament heavy (NF-H) subunits. Unexp...
Topics
- Amyotrophic Lateral Sclerosis
- Animals
- Axons
- Cell Death
- Gene Expression Regulation, Enzymologic
- Humans
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Neurofilament Proteins
- Superoxide Dismutase