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Article

Sequence variants in human neurofilament proteins: Absence of linkage to familial amyotrophic lateral sclerosis

1 Oct 1996

Abstract excerpt

Neurofilaments, assembled from NF-L (68 kd), NF-M (95 kd), and NF-H (115 kd), are the most abundant structural components in large myelinated axons, particularly those of motor neurons. Aberrant neurofilament accumulation in cell bodies and axons of motor neurons is a prominent pathological feature of several motor neuron diseases, including sporadic and familial amyotrophic lateral sclerosis (ALS). Transgenic...

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Identifiers

PMID: 8871580
DOI: 10.1002/ana.410400410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sequence variants in human neurofilament proteins: Absence of linkage to familial amyotrophic lateral sclerosisPMID 8871580Read ↗

Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis.Semantic proximity Read ↗

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Transgenic mice in the study of ALS: the role of neurofilaments.Semantic proximity Read ↗

Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosisSemantic proximity Read ↗

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Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.Semantic proximity Read ↗

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Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase.Semantic proximity Read ↗

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