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Article

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach.

Genome biology - 1 Jan 2014

Wong Daniel, Lee Wanseon, Humburg Peter, Makino Seiko, Lau Evelyn, Naranbhai Vivek, Fairfax Benjamin P, Chan Kenneth, Plant Katharine, Knight Julian C

Abstract excerpt

BACKGROUND: The master transactivator CIITA is essential to the regulation of Major Histocompatibility Complex (MHC)class II genes and an effective immune response. CIITA is known to modulate a small number of non-MHC genes involved in antigen presentation such as CD74 and B2M but its broader gen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25366989
DOI: 10.1186/s13059-014-0494-z
PMCID: PMC4243378

Genes

CIITA
ATF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25366989-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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