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Article

Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis.

British journal of cancer - 1 Nov 2000

Bouffler S D, Hofland N, Cox R, Fodde R

Abstract excerpt

The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC, Msh2Delta7N. Chromosome aberration frequencies were similar in bone marrow of Msh2(+/+), Msh2(+/-)and Msh2(-/-)mice and no differential effects of in vivo X-irradiation were noted. By contrast, the...

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Share to Base Pair Mismatch
Share to Chromosome Fragility
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Methylnitrosourea

Share to MutS Homolog 2 Protein

Share to Radiation, Ionizing

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Source

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Identifiers

PMID: 11044352
DOI: 10.1054/bjoc.2000.1422
PMCID: PMC2408782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11044352-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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