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Article

Prevalence of a Putative Efflux Mechanism among Fluoroquinolone-Resistant Clinical Isolates of <i>Streptococcus pneumoniae</i>

1 Aug 1998

Abstract excerpt

Twenty-three norfloxacin-selected first-step mutants of Streptococcus pneumoniae showed low-level fluoroquinolone resistance. Their susceptibility to norfloxacin in the presence or absence of reserpine and known efflux pump substrates was determined by an agar dilution method. Five mutants showed four- to eightfold increases in their susceptibility to norfloxacin in the presence of reserpine and four- to...

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PMID: 9687402
DOI: 10.1128/aac.42.8.2032

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