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Are fluoroquinolone-susceptible isolates of Streptococcus pneumoniae really susceptible? A comparison of resistance mechanisms in Canadian isolates from 1997 and 2003.

The Journal of antimicrobial chemotherapy - 1 Oct 2005

Schurek Kristen N, Adam Heather J, Siemens Christine G, Hoban Chris J, Hoban Daryl J, Zhanel George G

Abstract excerpt

OBJECTIVES: To assess the prevalence of efflux and amino acid substitutions in ParC and GyrA in Canadian clinical isolates of fluoroquinolone-susceptible Streptococcus pneumoniae with levofloxacin MICs of 1 mg/L collected before the introduction of the respiratory fluoroquinolones (1995-1997) and after 7 years of use (2003). METHODS: Quinolone resistance determining regions of parC and gyrA were sequenced for 111...

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PMID: 16126779
DOI: 10.1093/jac/dki315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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