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Article

Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement.

Immunology and cell biology - 1 Oct 2009

Keating Paula, O'Sullivan David, Tierney Joanna B, Kenwright Diane, Miromoeini Sara, Mawasse Lina, Brombacher Frank, La Flamme Anne C

Abstract excerpt

The administration of Th2 cytokines or immune deviation to a Th2 phenotypic response has been shown to protect against the autoimmune pathology of experimental autoimmune encephalomyelitis (EAE). To better understand the function of Th2 cytokines in the induction stage of EAE in the absence of an overt Th2 response, we immunized IL-4 receptor alpha-deficient (IL-4Ralpha(-/-)) mice, which are unable to respond to...

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Share to Adoptive Transfer
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19488061
DOI: 10.1038/icb.2009.37

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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