Article
IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2/IL-2Ralpha interaction.
Cancer research - 15 Dec 2000
Phillips K E, Herring B, Wilson L A, Rickford M S, Zhang M, Goldman C K, Tso J Y, Waldmann T A
Abstract excerpt
Adult T-cell leukemia (ATL) develops in a small proportion of human T-cell lymphotrophic virus-I infected individuals. The leukemia consists of an overabundance of activated T cells, which are characterized by the expression of CD25, or IL-2Ralpha, on their cell surface. Presently, there is not an accepted curative therapy for ATL. We developed an in vivo model of ATL in non-obese diabetic/severe combined...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.