Article
Novel arbekacin- and amikacin-modifying enzyme of methicillin-resistant Staphylococcus aureus.
FEMS microbiology letters - 15 Sept 2000
Fujimura S, Tokue Y, Takahashi H, Kobayashi T, Gomi K, Abe T, Nukiwa T, Watanabe A
Abstract excerpt
An aminoglycoside-modifying enzyme in arbekacin-resistant methicillin-resistant Staphylococcus aureus (MRSA), exhibiting 4'''-N-acetylation, was examined. Although the MRSA strain with AAC(4''') had no AAC(6')-APH(2") activity, a DNA fragment of the AAC(6')-APH(2") gene was amplified by PCR and the purified N-terminal 30-amino acid sequence of this AAC(4''') was identical to AAC(6')-APH(2"). Direct DNA sequencing...
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