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Article

Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.

Nature medicine - 1 Jan 2006

Robicsek Ari, Strahilevitz Jacob, Jacoby George A, Macielag Mark, Abbanat Darren, Park Chi Hye, Bush Karen, Hooper David C

Abstract excerpt

Antimicrobial-modifying resistance enzymes have traditionally been class specific, having coevolved with the antibiotics they inactivate. Fluoroquinolones, antimicrobial agents used extensively in medicine and agriculture, are synthetic and have been considered safe from naturally occurring antimicrobial-modifying enzymes. We describe reduced susceptibility to ciprofloxacin in clinical bacterial isolates...

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PMID: 16369542
DOI: 10.1038/nm1347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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