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Article

Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice.

Brain research - 13 Oct 2000

Hough L B, Nalwalk J W, Chen Y, Schuller A, Zhu Y, Zhang J, Menge W M, Leurs R, Timmerman H, Pintar J E

Abstract excerpt

Improgan is an analog of the H(2) antagonist cimetidine that does not act on known histamine receptors, but induces highly effective analgesia in rodents following intracerebroventricular (icv) administration. Since the mechanism of action of this compound remains unknown, improgan analgesia was characterized presently with the tail immersion nociceptive test in mutant mice lacking either the mu (exon 1 of...

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Source

Identifiers

PMID: 11032994
DOI: 10.1016/s0006-8993(00)02776-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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