Article
Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2009
Pan Ying-Xian, Xu Jin, Xu Mingming, Rossi Grace C, Matulonis Joshua E, Pasternak Gavril W
Abstract excerpt
Heroin remains a major drug of abuse and is preferred by addicts over morphine. Like morphine, heroin has high affinity and selectivity for mu-receptors, but its residual analgesia in exon 1 MOR-1 knockout mice that do not respond to morphine suggests a different mechanism of action. MOR-1 splice variants lacking exon 1 have been observed in mice, humans, and rats, raising the possibility that they might be...
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