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Article

mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality.

Brain research. Molecular brain research - 1 Mar 1998

Loh H H, Liu H C, Cavalli A, Yang W, Chen Y F, Wei L N

Abstract excerpt

The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that...

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Identifiers

PMID: 9555078
DOI: 10.1016/s0169-328x(97)00353-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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