Article
Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity.
Virology - 1 Dec 1994
Kimman T G, De Wind N, De Bruin T, de Visser Y, Voermans J
Abstract excerpt
To evaluate the contribution of glycoprotein E (gE), thymidine kinase (TK), and the US3-encoded protein kinase (PK) in the induction of protective immunity to pseudorabies virus (PRV), we intranasally inoculated pigs, the natural host of this virus, with mutant PRV strains in which the genes enco...
Topics
- Animals
- Antigens, Viral
- Cell Line
- Herpesvirus 1, Suid
- Mutation
- Neutralization Tests
- Protein Kinases
- Pseudorabies
- Swine
- Swine Diseases
- Thymidine Kinase
- Viral Envelope Proteins
- Virus Cultivation
- Virus Replication
- Virus Shedding