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Article

BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment.

BMC cancer - 22 Sept 2013

Ampuja Minna, Jokimäki Riikka, Juuti-Uusitalo Kati, Rodriguez-Martinez Alejandra, Alarmo Emma-Leena, Kallioniemi Anne

Abstract excerpt

BACKGROUND: Bone morphogenetic protein 4 (BMP4) belongs to the transforming growth factor β (TGF-β) family of proteins. BMPs regulate cell proliferation, differentiation and motility, and have also been reported to be involved in cancer pathogenesis. We have previously shown that BMP4 reduces breast cancer cell proliferation through G1 cell cycle arrest and simultaneously induces migration in a subset of these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24053318
DOI: 10.1186/1471-2407-13-429
PMCID: PMC3848934

Genes

BMP4
MMP14
MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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