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Article

Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.

International journal of oncology - 1 Oct 2000

Hijazi M M, Thompson E W, Tang C, Coopman P, Torri J A, Yang D, Mueller S C, Lupu R

Abstract excerpt

The metastatic process requires changes in tumor cell adhesion properties, cell motility and remodeling of the extracellular matrix. The erbB2 proto-oncogene is overexpressed in approximately 30% of breast cancers and is a major prognostic parameter when present in invasive disease. A ligand for the erbB2 receptor has not yet been identified but it can be activated by heterodimerization with heregulin...

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Identifiers

PMID: 10995872
DOI: 10.3892/ijo.17.4.629

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HRG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.PMID 10995872Read ↗

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase.Semantic proximity Read ↗

Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells.Semantic proximity Read ↗

Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta -catenin nuclear signaling in breast cancer cells by modulating the intercellular stability.Semantic proximity Read ↗

Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.Semantic proximity Read ↗

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis.Semantic proximity Read ↗

Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancerSemantic proximity Read ↗

Characterization of a P-Rex1 gene signature in breast cancer cellsSemantic proximity Read ↗

Identification of Heregulin, a Specific Activator of p185 <sup>erbB2</sup>Semantic proximity Read ↗

Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.Semantic proximity Read ↗

p38MAPK induces cell surface alpha4 integrin downregulation to facilitate erbB-2-mediated invasion.Semantic proximity Read ↗

c-erbB-2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells.Semantic proximity Read ↗

The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.Semantic proximity Read ↗

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