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Article

FH535 inhibited migration and growth of breast cancer cells.

PloS one - 1 Jan 2012

Iida Joji, Dorchak Jesse, Lehman John R, Clancy Rebecca, Luo Chunqing, Chen Yaqin, Somiari Stella, Ellsworth Rachel E, Hu Hai, Mural Richard J, Shriver Craig D

Abstract excerpt

There is substantial evidence indicating that the WNT signaling pathway is activated in various cancer cell types including breast cancer. Previous studies reported that FH535, a small molecule inhibitor of the WNT signaling pathway, decreased growth of cancer cells but not normal fibroblasts, su...

Read the complete abstract on PubMed

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Share to Adaptor Proteins, Signal Transducing
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Share to Chondroitin Sulfate Proteoglycans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Screening Assays, Antitumor

Share to Neoplasm Invasiveness

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Source

Open in PubMed Open full text

Identifiers

PMID: 22984505
DOI: 10.1371/journal.pone.0044418
PMCID: PMC3439405

Genes

CSPG4
NEDD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22984505-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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