Article
Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases.
Molecular cell - 1 Nov 1998
Zhou P, Howley P M
Abstract excerpt
The S. cerevisiae SCFCdc4p ubiquitin-protein ligase complex promotes cell cycle transitions through degradation of cell cycle regulators. To investigate SCFCdc4p regulation in vivo, we examined the stability of individual SCFCdc4p components. Whereas Cdc53p and Skp1p were stable, Cdc4p, the F box...
Topics
- Anaphase-Promoting Complex-Cyclosome
- CDC28 Protein Kinase, S cerevisiae
- Carrier Proteins
- Cell Cycle
- Cell Cycle Proteins
- Cullin Proteins
- Cyclins
- Cysteine Endopeptidases
- F-Box Proteins
- Fungal Proteins
- Half-Life
- Hydroxyurea
- Ligases
- Lipoproteins
- Multienzyme Complexes
- Mutation
- Nocodazole
- Pheromones