Article
Comparative analysis of HIV type 1 genotypic resistance across antiretroviral trial treatment regimens.
AIDS research and human retroviruses - 20 Sept 2000
Gilbert P B, Hanna G J, De Gruttola V, Martinez-Picado J, Kuritzkes D R, Johnson V A, Richman D D, D'Aquila R T
Abstract excerpt
From data on HIV-1 genotypes collected from antiretroviral trial participants who fail virologically, we describe methods for comparing distributions of acquired HIV-1 mutations across different treatment regimens. Given a definition of a "mutational distance" that summarizes the genetic change of a subject's virus in a way that captures the resistance cost of exposure to an antiretroviral regimen, these...
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