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Article

Interaction of genetic and environmental programming of the leptin system and of obesity disposition.

Physiological genomics - 9 Aug 2000

Schmidt I, Schoelch C, Ziska T, Schneider D, Simon E, Plagemann A

Abstract excerpt

Possible adverse interactions between an usually inconspicuous genetic trait and early environmental factors favoring the development of obesity were investigated in rats heterozygous for the leptin receptor defect "fatty" (fa). Pups were exposed to early postnatal overfeeding by reducing litter size from normally 10-12 to only 4. Rearing +/+ and +/fa pups from day 3 to 21 in small litters increased fat-free dry...

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Source

Identifiers

PMID: 11015606
DOI: 10.1152/physiolgenomics.2000.3.2.113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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