Article
The fa leptin receptor mutation and the heritability of respiratory frequency in a Brown Norway and Zucker intercross.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2004
Iyengar Sudha K, Stein Catherine M, Russo Karlie, Erokwu Bernadette O, Strohl Kingman P
Abstract excerpt
We sought to determine whether the fa (leptin receptor) mutation was a major determinant of the putative obesity effects on respiratory frequency in an intercross between the Brown Norway (low breathing frequency, nonobese strain) and the Zucker (moderately high breathing frequency, with the fa mutation) strains. The hypothesis was that rats bearing one (heterozygote) or two (homozygote) alleles of the Glu296Pro...
Topics
- Animals
- Hybridization, Genetic
- Mutation
- Obesity
- Quantitative Trait, Heritable
- Rats
- Rats, Zucker
- Receptors, Cell Surface
- Receptors, Leptin
- Respiration