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Article

5‘ → 3‘ Molecular Polarity of Human Replication Protein A (hRPA) Binding to Pseudo-Origin DNA Substrates

31 Aug 2000

Abstract excerpt

Human replication protein A (hRPA) was previously seen to efficiently bind a 48 bp simian virus 40 (SV40) "pseudo-origin" (PO) substrate that mimics a DNA structure found within the SV40 T antigen-origin (ori) complex. To understand the role of hRPA during the initiation of replication, we examined the PO sequence and structure requirements for hRPA interaction. Binding and unwinding were found to be most...

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PMID: 11009611
DOI: 10.1021/bi0005761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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