Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence

Abstract excerpt

Endothelial cells (ECs) undergo a limited number of cell divisions, ultimately stop dividing, and enter a state that is designated replicative senescence.Shortening of telomeres is believed to be a molecular clock that triggers senescence.Telomerase, a RNA-directed DNA polymerase, extends telomeres of eukaryotic chromosomes and delays the development of senescence.In this study, we examined telomere length and...

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• Share to Advanced biosensing and bioanalysis techniques
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Telomeres, Telomerase, and Senescence