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Article

Functional and gene expression analysis of hTERT overexpressed endothelial cells

1 Sept 2008

Abstract excerpt

Telomerase dysfunction contributes to cellular senescence. Recent advances indicate the importance of senescence in maintaining vascular cell function in vitro. Human telomerase reverse transcriptase (hTERT) overexpression is thought to lead to resistance to apoptosis and oxidative stress. However, the mechanism in endothelial lineage cells is unclear. We tried to generate an immortal endothelial cell line from...

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Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 19707384
DOI: 10.2147/btt.s2479

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