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Article

Splice variants reveal the region involved in oxygen sensing by recombinant human L-type Ca(2+) channels.

Circulation research - 29 Sept 2000

Fearon I M, Varadi G, Koch S, Isaacsohn I, Ball S G, Peers C

Abstract excerpt

Regulation of vascular smooth muscle Ca(2+) channels by oxygen tension contributes importantly to hypoxic vasodilatation. We previously described the inhibitory effects of hypoxia on the recombinant human cardiac L-type Ca(2+) channel alpha(1C) subunit (hHT isoform) expressed in HEK 293 cells. We now demonstrate that hypoxia inhibits only one of the three naturally occurring splice variants of this channel that...

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Identifiers

PMID: 11009556
DOI: 10.1161/01.res.87.7.537

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Splice variants reveal the region involved in oxygen sensing by recombinant human L-type Ca(2+) channels.PMID 11009556Read ↗

Analysis of oxygen-sensitive human cardiac L-type Ca2+ channel alpha1C subunit (hHT Isoform).Semantic proximity Read ↗

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