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Replication but Not Transcription of Simian Virus 40 DNA Is Dependent on Nuclear Domain 10

15 Oct 2000

Abstract excerpt

DNA viruses from several families including herpes simplex virus type 1, adenovirus type 5, and simian virus 40 (SV40), start their transcription and replication adjacent to a specific nuclear domain, ND10. We asked whether a specific viral DNA sequence determines the location of these synthetic activities at such restricted nuclear sites. Partial and overlapping SV40 sequences were introduced into a...

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PMID: 11000241
DOI: 10.1128/jvi.74.20.9694-9700.2000

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