Mutational analysis of single-stranded DNA templates active in the in vitro initiation assay for adenovirus DNA replication.

doi:10.1016/0042-6822(90)90377-4

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Article

Mutational analysis of single-stranded DNA templates active in the in vitro initiation assay for adenovirus DNA replication.

Virology - 1 Sept 1990

Dobbs L, Zhao L J, Sripad G, Padmanabhan R

Abstract excerpt

Three distinct domains, A, the minimal origin, as well as B and C, the binding sites for the host nuclear factors, are required for efficient initiation of adenovirus (Ad) DNA replication at the termini. The initiation reaction was examined using partially purified nuclear extracts and various si...

Topics

Adenoviruses, Human
Base Sequence
DNA Replication
DNA, Single-Stranded
DNA, Viral
HeLa Cells
Humans
Molecular Sequence Data
Mutation
Oligonucleotides
Plasmids
Templates, Genetic

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