Article
Tumor necrosis factor microsatellite polymorphism influences the development of insulin dependency in adult-onset diabetes patients with the DRB1*1502-DQB1*0601 allele and anti-glutamic acid decarboxylase antibodies.
The Journal of clinical endocrinology and metabolism - 1 Sept 2000
Obayashi H, Hasegawa G, Fukui M, Kamiuchi K, Kitamura A, Ogata M, Kanaitsuka T, Shigeta H, Kitagawa Y, Nakano K, Nishimura M, Ohta M, Nakamura N
Abstract excerpt
Recently, several studies have demonstrated that tumor necrosis factor microsatellite polymorphism (TNFalpha) contributes to the susceptibility of type 1 diabetes. This study investigates the influence of TNFalpha on the predisposition to insulin dependency in adult-onset diabetic patients with type 1 diabetes-protective human leukocyte antigen haplotypes. The TNFalpha of three groups of...
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