Article
Genetic polymorphism of the human tumor necrosis factor region in insulin-dependent diabetes mellitus. Linkage disequilibrium of TNFab microsatellite alleles with HLA haplotypes.
Human immunology - 1 Oct 1995
Monos D S, Kamoun M, Udalova I A, Csanky E, Cizman B, Turetskaya R L, Smirnova J B, Zharkov V G, Gasser D, Zmijewski C M
Abstract excerpt
The TNF region within the MHC includes a number of immunologically important genes. Microsatellites TNFa and TNFb adjacent to TNF exhibit extensive polymorphism. Employing a PCR-based technique, we identified TNFab haplotypes and defined their distribution in 97 controls and 48 diabetics of Caucasoid origin in a search for other genes within the MHC potentially associated with IDDM. Twenty-five different TNFab...
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