Article
Modulation of type 1 diabetes susceptibility by tumor necrosis factor alpha -308 G/A and lymphotoxin alpha +249 A/G haplotypes and lack of linkage disequilibrium with predisposing DQB1-DRB1 haplotypes in Bahraini patients.
Clinical and vaccine immunology : CVI - 1 Feb 2008
Stayoussef Mouna, Al-Jenaidi Fayza A, Al-Abbasi Abduljabbar, Al-Ola Khadija, Khayyat Haya, Mahjoub Touhami, Almawi Wassim Y
Abstract excerpt
Tumor necrosis factor alpha (TNF-alpha) -308 G/A and lymphotoxin alpha (LTalpha) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LTalpha +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-alpha/LTalpha alleles and susceptible/protective DRB1-DQB1...
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