Article
A combination of human leukocyte antigen DQB1*02 and the tumor necrosis factor alpha promoter G308A polymorphism predisposes to an insulin-deficient phenotype in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Jun 2003
Li Haiyan, Groop Leif, Nilsson Anita, Weng Jianping, Tuomi Tiinamaija
Abstract excerpt
Our previous results have suggested that genes outside the human leukocyte antigen (HLA) class II locus may affect the phenotype of type 2 diabetic patients from families with both type 1 and type 2 diabetes (mixed type 1/2). To study whether the TNF alpha gene could be such a modifying gene, we studied TNF alpha promoter polymorphisms (G-->A substitution at positions -308 and -238) in relation to HLA-DQB1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.