Article
Analysis of the domain requirement in Gas1 growth suppressing activity.
FEBS letters - 15 Sept 2000
Ruaro M E, Stebel M, Vatta P, Marzinotto S, Schneider C
Abstract excerpt
The product of the growth arrest specific gene, gas1, is a membrane-associated protein which activates a p53-dependent growth suppression signalling pathway. We have shown that Gas1 is linked to the plasma membrane through a glycosyl-phosphatidylinositol (GPI) anchor. Several GPI-anchored protein have been identified as part of receptor complexes either as co-receptors or as membrane bound ligands. In this...
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