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Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.

Lipids in health and disease - 2 Aug 2012

Kokaze Akatsuki, Ishikawa Mamoru, Matsunaga Naomi, Karita Kanae, Yoshida Masao, Shimada Naoki, Ohtsu Tadahiro, Shirasawa Takako, Ochiai Hirotaka, Satoh Masao, Hashimoto Masayasu, Hoshino Hiromi, Takashima Yutaka

Abstract excerpt

BACKGROUND: Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects. METHODS: A total of 394 male subjects (age, 53.9 ± 7.9 years;...

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Identifiers

PMID: 22857129
DOI: 10.1186/1476-511X-11-97
PMCID: PMC3459723

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