Article
Association of the neutral endopeptidase (MME) gene with anxiety.
Psychiatric genetics - 1 Jun 2000
Comings D E, Dietz G, Gade-Andavolu R, Blake H, Muhleman D, Huss M, Saucier G, MacMurray J P
Abstract excerpt
Enkephalins have been implicated in the regulation of mood, anxiety, reward, euphoria and pain. One of the major enzymes for enkephalin degradation is neutral endopeptidase [enkephalinase, membrane metalloendopeptidase (MME)]. We identified a dinucleotide polymorphism in the 5' region of the MME gene. Subjects were placed into three genotypes, 3/3, 3/x, and x/x since the 3 allele was the most common of the six...
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